LSU could be without two key offensive starters when it opens the season Sunday in Las Vegas against Southern Cal.

Wide receiver Chris Hilton’s bone bruise is the most serious of the two as head coach Brian Kelly listed him as “questionable” for the 6:30 p.m. kickoff.

Kelly was more optimistic about starting guard Miles Frazier, who has missed recent practices with a sprained ankle but was listed as “probable.”

Otherwise, the Tigers will head to Las Vegas in good shape — and, said Kelly, there are no players who will be unavailable for non-injury reasons.

Hilton, teamed with Kyren Lacey, is expected to give the Tigers their latest 1-2 punch at wide receiver, replacing first-round NFL draft picks Malik Nabers and Brian Robinson from a year ago.

“Chris will move around with our trainers (on Monday) and we’ll get a better sense of his situation. That’s why we’ve got him listed as questionable — we haven’t seen him move around.”

Frazier, Kelly said, “has been moving around and should practice for us Tuesday. That’s why we’ve got him listed as probable.”

Senior C.J. Daniels, a senior transfer from Liberty, is LSU’s third wide receiver, but the Tigers typically play five, sometimes six.

Redshirt freshman Kyle Parker would most likely pick up the slack if Hilton is unavailable.

“He’s had a great camp,” Kelly said. “We really feel good about what he could do for us.”

Other possibilities would be transfers Aaron Adams (Alabama) and Zavion Thomas (Mississippi State), both of whom are also involved in kick returns.

Both Hilton and Lacy saw considerable playing time a year ago when Nabers and Robinson were filling up the stat sheet.

Lacy was the top wide receiver beyond the dynamic duo a year ago, with 30 receptions for 558 yards and seven touchdowns.

Hilton made 13 catches for 225 yards, but the speedster came on strong toward the end of the season.

Kelly has said he expects to have a more balanced attack with a more traditional rushing attack after Heisman Trophy winner Jayden Daniels accounted for almost half the Tigers’ rushing yards a season ago.

The Tigers have what many analysts consider the best offensive line in the Southeastern Conference, if not the country, with four returning starters. But there is little proven depth beyond the first string.

Kelly said, if needed, the most likely replacement for Frazier would be Tyree Adams, a 6-foot-7, 313-pound freshman.

Sophomore Paul Mubenga would be another possibility.

“We’ve got a lot of moving pieces, where some guys know multiple positions,” Kelly added.

Overall, the coach he said he feels good about starting the season with a mature team despite the losses of the three key playmakers.

But going into his third year with LSU, the Tigers, have yet to win their season opener, both losses to Florida State in neutral-site games that had similar build-up as Sunday’s meeting with USC.

“Openers are difficult,” he said. “You practice so much, there’s so much practice … and then you have to flip the switch to performance, where you have to perform at a high level … where you have to execute at a high level in your opener.

“So I think every coach has that uneasiness. You don’t know what you’re going to get when you flip that switch.

“We’re expecting much better execution with this group because of the maturity of the team.

“What’s the complexion of your team going to be? Winning and losing is such a fine line. A lot of times it can be just what the mind-set of your team is? We don’t have the playmakers, maybe, that we had last year. (But) we have great leadership. We have guys with experience, we have guys that hold each other accountable …

“This group understands what it takes to be successful and I expect them to continue to do that.”