Forgotten vials of smallpox found in storage room

By By The Associated Press

ATLANTA — A government scientist cleaning out an old storage room at a research center near Washington made a startling

discovery last week — decades-old vials of smallpox packed away and forgotten in a cardboard box.

The six glass vials were intact and sealed, and scientists have yet to establish whether the virus is dead or alive, the Centers

for Disease Control and Prevention said Tuesday.

Still, the find was disturbing because for decades after smallpox was declared eradicated in 1980, world health authorities

said the only known samples left were safely stored in super-secure laboratories in Atlanta and in Russia.

Officials said this is the first time in the U.S. that unaccounted-for smallpox has been discovered. At least one leading

scientist raised the possibility that there are more such vials out there around the world.

The CDC and the FBI are investigating.

It was the second recent incident in which a U.S. government health agency appeared to have mishandled a highly dangerous

germ. Last month, scores of CDC employees in Atlanta were feared exposed to anthrax because of a laboratory safety lapse.

The CDC began giving them antibiotics as a precaution.

The freeze-dried smallpox samples were found in a building at the National Institutes of Health in Bethesda, Maryland, that

has been used by the Food and Drug Administration since 1972, according to the CDC.

The scientist was cleaning out a cold room between two laboratories on July 1 when he made the discovery, FDA officials said.

Officials said labeling indicated the smallpox had been put in the vials in the 1950s. But they said it's not clear how long

the vials had been in the building, which did not open until the 1960s.

No one has been infected, and no smallpox contamination was found in the building.

Smallpox can be deadly even after it is freeze-dried, but the virus usually has to be kept cold to remain alive and dangerous.

In an interview Tuesday, a CDC official said he believed the vials were stored for many years at room temperature, which would

suggest the samples are dead. But FDA officials said later in the day that the smallpox was in cold storage for decades.

"We don't yet know if it's live and infectious," said Stephan Monroe, deputy director of the CDC center that handles highly

dangerous infectious agents.

The samples were rushed under FBI protection to the CDC in Atlanta for testing, which could take a few weeks. After that,

they will be destroyed.

Peter Marks, deputy director of the FDA's

Center for Biologics Research and Evaluation, said the discovery was

unexpected

but not a total shock. He added, however, that "no one's denying

we should have done a better job cleaning out what was there."

In at least one other such episode, vials of

smallpox were found at the bottom of a freezer in an Eastern European

country

in the 1990s, according to Dr. David Heymann, a former World

Health Organization official who is now a professor at the London

School of Hygiene and Tropical Medicine.

Heymann said that when smallpox samples were gathered up for destruction decades ago, requests went out to ministers of health

to collect all vials.

"As far as I know, there was never a confirmation they had checked in with all groups who could have had the virus," he said.

Dr. Donald "D.A." Henderson, who led the WHO

smallpox-eradication effort and is now a professor at the Center for

Health Security

at the University of Pittsburgh, said it is highly unlikely more

such stashes will be discovered. But he conceded "things

were pretty casual" in the 1950s.

Decades ago, he recalled, "I came back from many a trip carrying specimens, and I just put them in the refrigerator until

I could get them to a laboratory. My wife didn't appreciate that."

Smallpox was one of the most lethal diseases in history. For centuries, it killed about one-third of the people it infected,

and left most survivors with deep scars on their faces from the pus-filled lesions.

The last known case was in Britain in 1978, when a university photographer who worked above a lab handling smallpox died after

being accidentally exposed to it through the ventilation system.

Global vaccination campaigns finally brought smallpox under control. After it was declared eradicated, all known remaining

samples of live virus were stored at a CDC lab in Atlanta and at a Russian lab in Novosibirsk, Siberia.

The labs take extreme precautions. Scientists must undergo fingerprint or retinal scans to get inside, they wear full-body

suits including gloves and goggles, and they shower with strong disinfectant before leaving the labs.

There has long been debate over whether to destroy the stockpile.

Many scientists argue that any remaining

samples pose a threat and that the deadly virus should be wiped off the

planet altogether.

Others contend the samples are needed for research on better

treatments and vaccines.

At its recent annual meeting in May, WHO put off a decision again.